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首页 > 技术文章 >意大利PSI微射流均质机的在线清洗与在线灭菌(CIP、SIP)

意大利PSI微射流均质机的在线清洗与在线灭菌(CIP、SIP)

 更新时间:2024-02-29  点击量:2140

在制药、食品、饮料、化妆品等多个领域,对生产设备进行充分及时的清洗和灭菌处理一直都是生产工艺环节中相当重要的步骤。如制剂生产过程中残留的原辅料、不溶性微粒,食品饮料生产过程中残留的微生物等等。为避免这些残留物对下批产品产生不良影响,清洗和灭菌工序便*。

在新版药品生产质量管理规范(GMP)第五章关于设备的第七十四条内容中提到:设备的设计、选型、安装、改造和维护必须符合预定用途,应尽可能降低发生污染、交叉污染、混淆和差错,便于操作、清洁、维护,以及必要时进行的消毒或灭菌。

大多实验室、部分工厂对于生产设备的清洗采用的是人工清洗方式,虽然在一定程度上人工清洗能够解决物料间的交叉污染并达到基础的灭菌效果,但其毕竟属于主观性较强且不可控的一种清洗方式。因而在规范的生产、研究过程中,使用标准化较强、清洗灭菌更为的设备进行在线清洗(CIP)和在线灭菌(SIP)是用于控制微生物、残留物污染及产品安全性的重要手段。

在线清洗(Clean in place,CIP)也叫原位清洗,通常指系统或较大型设备在原安装位置不作拆卸及移动条件下的清洁工作。意大利PSI微射流均质机的所有型号(PSI-20、PSI-40、PSI Infinity)几乎就是为方便在线清洗(CIP)而设计的:从进料端至出料端的每一个与物料接触的部件都无需拆卸,内部*。

 

 

图1 常规生产设备内部难清洗的死角                图2 PSI设备的*设计

 

所有与物料接触的管件都采用医用级清洁材质316L电抛光不锈钢,符合ASME BPE的卫生级管件标准。更不用说在采用人工清洗时,PSI微射流均质机所用的容易清洗、拆装方便的部件,以及管件连接处采用卡箍、三夹卡钳等模式可满足“快装、快开、快换”的易拆卸清洗特点。

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" />               

    图3 ASME BPE卫生级管件                                         图4 电抛光洁净表面

 

在线灭菌(Sterilization in place,SIP)即系统或设备在原安装位置不作拆卸及移动条件下的蒸汽灭菌。其目的是控制住微生物的数量使其在一定的污染水平内。SIP的介质可以热水、蒸汽、消毒剂等,《中国药典》2015年版1421章节 灭菌法中规定:“湿热灭菌条件通常采用121℃、15min, 121℃、30min,116℃、40min的程序,也可采用其他温度和时间参数,但无论采用何种灭菌温度和时间参数,都必须证明所采用的灭菌工艺和监控措施在日常运行过程中能确保物品灭菌后的无菌水平(sterility assurance level,SAL)不得高于10-6。也有企业采取超过130℃的温度进行灭菌,而如果不是无菌设备,做SIP时温度则无需在100℃以上。

对于PSI微射流均质机而言,其封闭、*的回路充分满足CIP、SIP程序,可通过简单的进出口管件更换以安装相应的在线清洗设备或高压灭菌器等。注意,由于微射流均质机本身属于高压设备,其内部的高压密封圈、柱塞密封圈等可能会因为暴露在高温高压蒸汽下而失去密封效果,因此使用高温蒸汽进行清洗灭菌时,请勿超过20000psi的高压。

许多使用意大利PSI高压微射流均质机的制药企业会采取化学清洗的方式进行灭菌,如异丙醇溶液、氢氧化钠溶液等都可将设备内部的微生物控制在较低的水平。